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Keratin 8 reduces colonic permeability and maintains gut microbiota homeostasis, protecting against colitis and colitis-associated tumorigenesis

Keratin 8 (CK8) is the major component of the intermediate filaments of simple or single-layered epithelia. Gene targeting mice model suggest that CK8 is involved in colonic active ion transport, colorectal hyperplasia and inflammation. In the present study, we found that CK8 is downregulated in the...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Liu, Chao, Liu, En-Dong, Meng, Yun-Xiao, Dong, Xiao-Ming, Bi, Ya-Lan, Wu, Huan-Wen, Jin, Yan-Chao, Zhao, Ke, Li, Jian-Jie, Yu, Miao, Zhan, Yi-Qun, Chen, Hui, Ge, Chang-Hui, Yang, Xiao-Ming, Li, Chang-Yan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722522/
https://ncbi.nlm.nih.gov/pubmed/29228570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18241
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