BRAF(V600E) Mutations in High Grade Colorectal Neuroendocrine Tumors May Predict Responsiveness to BRAF-MEK Combination Therapy

Neuroendocrine tumors comprise a heterogeneous group of malignancies with a broad spectrum of clinical behavior. Poorly differentiated tumors follow an aggressive course with limited treatment options, and new approaches are needed. Oncogenic BRAF V600E (BRAF(V600E)) substitutions are observed prima...

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Detaylı Bibliyografya
Yayımlandı:Cancer Discov
Asıl Yazarlar: Klempner, Samuel J., Gershenhorn, Bruce, Tran, Phu, Lee, Thomas K., Erlander, Mark G., Gowen, Kyle, Schrock, Alexa B., Morosini, Deborah, Ross, Jeffrey S., Miller, Vincent A., Stephens, Philip J., Ignatius Ou, Sai-Hong, Ali, Siraj M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008024/
https://ncbi.nlm.nih.gov/pubmed/27048246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-1192
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