BRAF(V600E) Mutations in High Grade Colorectal Neuroendocrine Tumors May Predict Responsiveness to BRAF-MEK Combination Therapy

Neuroendocrine tumors comprise a heterogeneous group of malignancies with a broad spectrum of clinical behavior. Poorly differentiated tumors follow an aggressive course with limited treatment options, and new approaches are needed. Oncogenic BRAF V600E (BRAF(V600E)) substitutions are observed prima...

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Bibliographic Details
Published in:Cancer Discov
Main Authors: Klempner, Samuel J., Gershenhorn, Bruce, Tran, Phu, Lee, Thomas K., Erlander, Mark G., Gowen, Kyle, Schrock, Alexa B., Morosini, Deborah, Ross, Jeffrey S., Miller, Vincent A., Stephens, Philip J., Ignatius Ou, Sai-Hong, Ali, Siraj M.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008024/
https://ncbi.nlm.nih.gov/pubmed/27048246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-1192
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