BRAF(V600E) Mutations in High Grade Colorectal Neuroendocrine Tumors May Predict Responsiveness to BRAF-MEK Combination Therapy

Neuroendocrine tumors comprise a heterogeneous group of malignancies with a broad spectrum of clinical behavior. Poorly differentiated tumors follow an aggressive course with limited treatment options, and new approaches are needed. Oncogenic BRAF V600E (BRAF(V600E)) substitutions are observed prima...

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Gepubliceerd in:Cancer Discov
Hoofdauteurs: Klempner, Samuel J., Gershenhorn, Bruce, Tran, Phu, Lee, Thomas K., Erlander, Mark G., Gowen, Kyle, Schrock, Alexa B., Morosini, Deborah, Ross, Jeffrey S., Miller, Vincent A., Stephens, Philip J., Ignatius Ou, Sai-Hong, Ali, Siraj M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008024/
https://ncbi.nlm.nih.gov/pubmed/27048246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-1192
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