Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin

Histone deacetylase inhibitors (HDACi) induce acetylation of histone and non-histone proteins, and modulate the acetylation of proteins involved in DNA double-strand break (DSB) repair. Non-homologous end-joining (NHEJ) is one of the main pathways for repairing DSBs. Decreased NHEJ activity has been...

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Publicado en:Leuk Res
Main Authors: Robert, Carine, Nagaria, Pratik K., Pawar, Nisha, Adewuyi, Adeoluwa, Gojo, Ivana, Meyers, David J., Cole, Philip A., Rassool, Feyruz V.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007632/
https://ncbi.nlm.nih.gov/pubmed/27064363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2016.03.007
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