Metastasis Suppressor NME1 Modulates Choice of Double-Strand Break Repair Pathways in Melanoma Cells by Enhancing Alternative NHEJ while Inhibiting NHEJ and HR

Reduced NME1 expression in melanoma cell lines, mouse models of melanoma, and melanoma specimens in human patients is associated with increased metastatic activity. Herein, we investigate the role of NME1 in repair of double-stranded breaks (DSBs) and choice of double-strand break repair (DSBR) path...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Puts, Gemma, Jarrett, Stuart, Leonard, Mary, Matsangos, Nicolette, Snyder, Devin, Wang, Ying, Vincent, Richard, Portney, Benjamin, Abbotts, Rachel, McLaughlin, Lena, Zalzman, Michal, Rassool, Feyruz, Kaetzel, David
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7460576/
https://ncbi.nlm.nih.gov/pubmed/32824412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21165896
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