Rhesus θ-defensin-1 (RTD-1) exhibits in vitro and in vivo activity against cystic fibrosis strains of Pseudomonas aeruginosa

OBJECTIVES: Chronic endobronchial infections with Pseudomonas aeruginosa contribute to bronchiectasis and progressive loss of lung function in patients with cystic fibrosis. This study aimed to evaluate the therapeutic potential of a novel macrocyclic peptide, rhesus θ-defensin-1 (RTD-1), by charact...

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Vydáno v:J Antimicrob Chemother
Hlavní autoři: Beringer, Paul M., Bensman, Timothy J., Ho, Henry, Agnello, Melissa, Denovel, Nicole, Nguyen, Albert, Wong-Beringer, Annie, She, Rosemary, Tran, Dat Q., Moskowitz, Samuel M., Selsted, Michael E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007590/
https://ncbi.nlm.nih.gov/pubmed/26433781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv301
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