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Efficient one-pot cyclization/folding of Rhesus θ-defensin-1 (RTD-1)
We report an efficient approach for the chemical synthesis of Rhesus θ-defensin-1 (RTD-1) using Fmoc-based solid-phase peptide synthesis in combination with an intramolecular version of native chemical ligation. The corresponding linear thioester precursor was cyclized and folded in a one-pot reacti...
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Autores principales: | , , , , , |
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Formato: | Artigo |
Lenguaje: | Inglês |
Publicado: |
2012
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Materias: | |
Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3590006/ https://ncbi.nlm.nih.gov/pubmed/22425570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.02.080 |
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