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Full sequence amino acid scanning of θ-defensin RTD-1 yields a potent anthrax lethal factor protease inhibitor
θ-Defensin RTD-1 is a non-competitive inhibitor of anthrax lethal factor (LF) protease (IC(50) = 390 ± 20 nM, K(i) = 365 ± 20 nM) and a weak inhibitor of other mammalian metalloproteases such as TNFα converting enzyme (TACE) (K(i) = 4.45 ± 0.48 μM). Using full sequence amino acid scanning in combina...
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| Published in: | J Med Chem |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5807008/ https://ncbi.nlm.nih.gov/pubmed/28151653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01689 |
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