Live Attenuated Leishmania donovani Centrin Knock Out Parasites Generate Non-inferior Protective Immune Response in Aged Mice against Visceral Leishmaniasis

BACKGROUND: Visceral leishmaniasis (VL) caused by the protozoan parasite Leishmania donovani causes severe disease. Age appears to be critical in determining the clinical outcome of VL and at present there is no effective vaccine available against VL for any age group. Previously, we showed that gen...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Bhattacharya, Parna, Dey, Ranadhir, Dagur, Pradeep K., Joshi, Amritanshu B., Ismail, Nevien, Gannavaram, Sreenivas, Debrabant, Alain, Akue, Adovi D., KuKuruga, Mark A., Selvapandiyan, Angamuthu, McCoy, John Philip, Nakhasi, Hira L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007048/
https://ncbi.nlm.nih.gov/pubmed/27580076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004963
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