Live Attenuated Leishmania donovani Centrin Knock Out Parasites Generate Non-inferior Protective Immune Response in Aged Mice against Visceral Leishmaniasis

BACKGROUND: Visceral leishmaniasis (VL) caused by the protozoan parasite Leishmania donovani causes severe disease. Age appears to be critical in determining the clinical outcome of VL and at present there is no effective vaccine available against VL for any age group. Previously, we showed that gen...

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Dades bibliogràfiques
Publicat a:PLoS Negl Trop Dis
Autors principals: Bhattacharya, Parna, Dey, Ranadhir, Dagur, Pradeep K., Joshi, Amritanshu B., Ismail, Nevien, Gannavaram, Sreenivas, Debrabant, Alain, Akue, Adovi D., KuKuruga, Mark A., Selvapandiyan, Angamuthu, McCoy, John Philip, Nakhasi, Hira L.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007048/
https://ncbi.nlm.nih.gov/pubmed/27580076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004963
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