Genetically Modified Live Attenuated Leishmania donovani Parasites Induce Innate Immunity through Classical Activation of Macrophages That Direct the Th1 Response in Mice

Visceral leishmaniasis (VL) causes significant mortality and there is no effective vaccine. Previously, we have shown that genetically modified Leishmania donovani parasites, here described as live attenuated parasites, induce a host protective adaptive immune response in various animal models. In t...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Bhattacharya, Parna, Dey, Ranadhir, Dagur, Pradeep K., Kruhlak, Michael, Ismail, Nevien, Debrabant, Alain, Joshi, Amritanshu B., Akue, Adovi, Kukuruga, Mark, Takeda, Kazuyo, Selvapandiyan, Angamuthu, McCoy, John Philip, Nakhasi, Hira L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567628/
https://ncbi.nlm.nih.gov/pubmed/26169275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00184-15
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