Genetically Modified Live Attenuated Leishmania donovani Parasites Induce Innate Immunity through Classical Activation of Macrophages That Direct the Th1 Response in Mice

Visceral leishmaniasis (VL) causes significant mortality and there is no effective vaccine. Previously, we have shown that genetically modified Leishmania donovani parasites, here described as live attenuated parasites, induce a host protective adaptive immune response in various animal models. In t...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Bhattacharya, Parna, Dey, Ranadhir, Dagur, Pradeep K., Kruhlak, Michael, Ismail, Nevien, Debrabant, Alain, Joshi, Amritanshu B., Akue, Adovi, Kukuruga, Mark, Takeda, Kazuyo, Selvapandiyan, Angamuthu, McCoy, John Philip, Nakhasi, Hira L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567628/
https://ncbi.nlm.nih.gov/pubmed/26169275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00184-15
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