Genetically Modified Live Attenuated Leishmania donovani Parasites Induce Innate Immunity through Classical Activation of Macrophages That Direct the Th1 Response in Mice

Visceral leishmaniasis (VL) causes significant mortality and there is no effective vaccine. Previously, we have shown that genetically modified Leishmania donovani parasites, here described as live attenuated parasites, induce a host protective adaptive immune response in various animal models. In t...

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Dades bibliogràfiques
Publicat a:Infect Immun
Autors principals: Bhattacharya, Parna, Dey, Ranadhir, Dagur, Pradeep K., Kruhlak, Michael, Ismail, Nevien, Debrabant, Alain, Joshi, Amritanshu B., Akue, Adovi, Kukuruga, Mark, Takeda, Kazuyo, Selvapandiyan, Angamuthu, McCoy, John Philip, Nakhasi, Hira L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
Matèries:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567628/
https://ncbi.nlm.nih.gov/pubmed/26169275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00184-15
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