mTORC2 responds to glutamine catabolite levels to modulate the hexosamine biosynthesis enzyme GFAT1

Highly proliferating cells are particularly dependent on glucose and glutamine for bioenergetics and macromolecule biosynthesis. The signals that respond to nutrient fluctuations to maintain metabolic homeostasis remain poorly understood. Here, we found that mTORC2 is activated by nutrient deprivati...

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Publicat a:Mol Cell
Autors principals: Moloughney, Joseph G., Kim, Peter K., Vega-Cotto, Nicole M., Wu, Chang-Chih, Zhang, Sisi, Adlam, Matthew, Lynch, Thomas, Chou, Po-Chien, Rabinowitz, Joshua D., Werlen, Guy, Jacinto, Estela
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006067/
https://ncbi.nlm.nih.gov/pubmed/27570073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.07.015
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