mTORC2 modulates the amplitude and duration of GFAT1 Ser-243 phosphorylation to maintain flux through the hexosamine pathway during starvation

The mechanistic target of rapamycin (mTOR) controls metabolic pathways in response to nutrients. Recently, we have shown that mTOR complex 2 (mTORC2) modulates the hexosamine biosynthetic pathway (HBP) by promoting the expression of the key enzyme of the HBP, glutamine:fructose-6-phosphate aminotran...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Moloughney, Joseph G., Vega-Cotto, Nicole M., Liu, Sharon, Patel, Chadni, Kim, Peter K., Wu, Chang-chih, Albaciete, Danielle, Magaway, Cedric, Chang, Austin, Rajput, Swati, Su, Xiaoyang, Werlen, Guy, Jacinto, Estela
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200946/
https://ncbi.nlm.nih.gov/pubmed/30201609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003991
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