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mTORC2 responds to glutamine catabolite levels to modulate the hexosamine biosynthesis enzyme GFAT1
Highly proliferating cells are particularly dependent on glucose and glutamine for bioenergetics and macromolecule biosynthesis. The signals that respond to nutrient fluctuations to maintain metabolic homeostasis remain poorly understood. Here, we found that mTORC2 is activated by nutrient deprivati...
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| Publicado no: | Mol Cell |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5006067/ https://ncbi.nlm.nih.gov/pubmed/27570073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.07.015 |
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