Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies

We dissected the importance of human telomerase biogenesis and trafficking pathways for telomere maintenance. Biological stability of human telomerase RNA (hTR) relies on H/ACA proteins, but other eukaryotes use other RNP assembly pathways. To investigate additional rationale for human telomerase as...

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Vydáno v:eLife
Hlavní autoři: Vogan, Jacob M, Zhang, Xiaozhu, Youmans, Daniel T, Regalado, Samuel G, Johnson, Joshua Z, Hockemeyer, Dirk, Collins, Kathleen
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2016
Témata:
Genes and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5005035/
https://ncbi.nlm.nih.gov/pubmed/27525486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18221
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