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Telomerase Recruitment Requires both TCAB1 and Cajal Bodies Independently
The ability of most cancer cells to grow indefinitely relies on the enzyme telomerase and its recruitment to telomeres. In human cells, recruitment depends on the Cajal body RNA chaperone TCAB1 binding to the RNA subunit of telomerase (hTR) and is also thought to rely on an N-terminal domain of the...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3434490/ https://ncbi.nlm.nih.gov/pubmed/22547674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00379-12 |
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