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Telomerase Reverse Transcriptase Is Required for the Localization of Telomerase RNA to Cajal Bodies and Telomeres in Human Cancer Cells

Telomere maintenance by telomerase is critical for the unlimited division potential of most human cancer cells. The two essential components of human telomerase, telomerase RNA (hTR) and telomerase reverse transcriptase (hTERT), are recruited from distinct subnuclear sites to telomeres during S phas...

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Autors principals: Tomlinson, Rebecca L., Abreu, Eladio B., Ziegler, Tania, Ly, Hinh, Counter, Christopher M., Terns, Rebecca M., Terns, Michael P.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2526684/
https://ncbi.nlm.nih.gov/pubmed/18562689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-02-0184
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