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Telomerase Recruitment Requires both TCAB1 and Cajal Bodies Independently

The ability of most cancer cells to grow indefinitely relies on the enzyme telomerase and its recruitment to telomeres. In human cells, recruitment depends on the Cajal body RNA chaperone TCAB1 binding to the RNA subunit of telomerase (hTR) and is also thought to rely on an N-terminal domain of the...

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Sonraí Bibleagrafaíochta
Main Authors: Stern, J. Lewis, Zyner, Katherine G., Pickett, Hilda A., Cohen, Scott B., Bryan, Tracy M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434490/
https://ncbi.nlm.nih.gov/pubmed/22547674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00379-12
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