Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling

NADPH oxidases (Noxes) produce ROS that regulate cell growth and death. NOX4 expression in cardiomyocytes (CMs) plays an important role in cardiac remodeling and injury, but the posttranslational mechanisms that modulate this enzyme are poorly understood. Here, we determined that FYN, a Src family t...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Matsushima, Shouji, Kuroda, Junya, Zhai, Peiyong, Liu, Tong, Ikeda, Shohei, Nagarajan, Narayani, Oka, Shin-ichi, Yokota, Takashi, Kinugawa, Shintaro, Hsu, Chiao-Po, Li, Hong, Tsutsui, Hiroyuki, Sadoshima, Junichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004961/
https://ncbi.nlm.nih.gov/pubmed/27525436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85624
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