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Stimulating the RIG-I pathway to kill cells in the latent HIV reservoir following viral reactivation
The persistence of latent HIV proviruses in long-lived CD4(+) T cells despite antiretroviral therapy (ART)(1–3) is a major obstacle to viral eradication(4–6). Because current candidate latency-reversing agents (LRAs) induce HIV transcription but fail to clear these cellular reservoirs,(7–8) new appr...
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| Pubblicato in: | Nat Med |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5004598/ https://ncbi.nlm.nih.gov/pubmed/27294875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4124 |
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