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Implementation of adaptive methods in early-phase clinical trials
There has been constant development of novel statistical methods in the design of early-phase clinical trials since the introduction of model-based designs, yet the traditional or modified 3+3 algorithmic design remains the most widely used approach in dose-finding studies. Research has shown the li...
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| Publicado no: | Stat Med |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5003756/ https://ncbi.nlm.nih.gov/pubmed/26928191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6910 |
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