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Statistical controversies in clinical research: early-phase adaptive design for combination immunotherapies
BACKGROUND: In recent years, investigators have asserted that the 3 + 3 design lacks flexibility, making its use in modern early-phase trial settings, such as combinations and/or biological agents, inefficient. More innovative approaches are required to address contemporary research questions, such...
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| Publicado no: | Ann Oncol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5834099/ https://ncbi.nlm.nih.gov/pubmed/28011450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdw681 |
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