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Statistical controversies in clinical research: early-phase adaptive design for combination immunotherapies

BACKGROUND: In recent years, investigators have asserted that the 3 + 3 design lacks flexibility, making its use in modern early-phase trial settings, such as combinations and/or biological agents, inefficient. More innovative approaches are required to address contemporary research questions, such...

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Опубликовано в: :Ann Oncol
Главные авторы: Wages, N. A., Slingluff, C. L., Petroni, G. R.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834099/
https://ncbi.nlm.nih.gov/pubmed/28011450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdw681
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