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Statistical controversies in clinical research: requiem for the 3 + 3 design for phase I trials
BACKGROUND: More than 95% of published phase I trials have used the 3 + 3 design to identify the dose to be recommended for phase II trials. However, the statistical community agrees on the limitations of the 3 + 3 design compared with model-based approaches. Moreover, the mechanisms of action of ta...
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| Publicado no: | Ann Oncol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4551156/ https://ncbi.nlm.nih.gov/pubmed/26088197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdv266 |
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