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Implementation of adaptive methods in early-phase clinical trials

There has been constant development of novel statistical methods in the design of early-phase clinical trials since the introduction of model-based designs, yet the traditional or modified 3+3 algorithmic design remains the most widely used approach in dose-finding studies. Research has shown the li...

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Bibliografiska uppgifter
I publikationen:Stat Med
Huvudupphovsmän: Petroni, Gina R., Wages, Nolan A., Paux, Gautier, Dubois, Frédéric
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003756/
https://ncbi.nlm.nih.gov/pubmed/26928191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6910
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