Isoform-specific targeting of ROCK proteins in immune cells

Rho-associated kinase 1 (ROCK1) and ROCK2 are activated by Rho GTPase and control cytoskeleton rearrangement through modulating the phosphorylation of their down-stream effector molecules. Although these 2 isoforms share more than 90% homology within their kinase domain the question of whether ROCK...

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Vydáno v:Small GTPases
Hlavní autoři: Zanin-Zhorov, Alexandra, Flynn, Ryan, Waksal, Samuel D., Blazar, Bruce R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
Témata:
Commentaries
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003547/
https://ncbi.nlm.nih.gov/pubmed/27254302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2016.1181698
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