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Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Ferroptosis is form of regulated nonapoptotic cell death that is involved in diverse disease contexts. Small molecules that inhibit glutathione peroxidase 4 (GPX4), a phospholipid peroxidase, cause lethal accumulation of lipid peroxides and induce ferroptotic cell death. Although ferroptosis has bee...

詳細記述

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Yang, Wan Seok, Kim, Katherine J., Gaschler, Michael M., Patel, Milesh, Shchepinov, Mikhail S., Stockwell, Brent R.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003261/
https://ncbi.nlm.nih.gov/pubmed/27506793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603244113
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