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Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
Ferroptosis is form of regulated nonapoptotic cell death that is involved in diverse disease contexts. Small molecules that inhibit glutathione peroxidase 4 (GPX4), a phospholipid peroxidase, cause lethal accumulation of lipid peroxides and induce ferroptotic cell death. Although ferroptosis has bee...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5003261/ https://ncbi.nlm.nih.gov/pubmed/27506793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603244113 |
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