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Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

Ferroptosis is a cell death process driven by damage to cell membranes and linked to numerous human diseases. Ferroptosis is caused by loss of activity of the key enzyme that is tasked with repairing oxidative damage to cell membranes—glutathione peroxidase 4 (GPX4). GPX4 normally removes the danger...

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Détails bibliographiques
Publié dans:PLoS Biol
Auteurs principaux: Feng, Huizhong, Stockwell, Brent R.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991413/
https://ncbi.nlm.nih.gov/pubmed/29795546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2006203
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