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Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

Ferroptosis is a cell death process driven by damage to cell membranes and linked to numerous human diseases. Ferroptosis is caused by loss of activity of the key enzyme that is tasked with repairing oxidative damage to cell membranes—glutathione peroxidase 4 (GPX4). GPX4 normally removes the danger...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Biol
Prif Awduron: Feng, Huizhong, Stockwell, Brent R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991413/
https://ncbi.nlm.nih.gov/pubmed/29795546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2006203
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