Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein

The aggregation of α-synuclein (aSyn) leading to the formation of Lewy bodies is the defining pathological hallmark of Parkinson’s disease (PD). Rare familial PD-associated mutations in aSyn render it aggregation-prone; however, PD patients carrying wild type (WT) aSyn also have aggregated aSyn in L...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Wang, Wei, Nguyen, Linh T. T., Burlak, Christopher, Chegini, Fariba, Guo, Feng, Chataway, Tim, Ju, Shulin, Fisher, Oriana S., Miller, David W., Datta, Debajyoti, Wu, Fang, Wu, Chun-Xiang, Landeru, Anuradha, Wells, James A., Cookson, Mark R., Boxer, Matthew B., Thomas, Craig J., Gai, Wei Ping, Ringe, Dagmar, Petsko, Gregory A., Hoang, Quyen Q.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003239/
https://ncbi.nlm.nih.gov/pubmed/27482083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610099113
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