Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice

Developing therapeutics for neurodegenerative diseases (NDs) prevalent in the aging population remains a daunting challenge. With the growing understanding that many NDs progress by conformational self-templating of specific proteins, the prototypical prion diseases offer a platform for ND drug disc...

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Bibliographic Details
Published in:J Pharmacol Exp Ther
Main Authors: Giles, Kurt, Berry, David B., Condello, Carlo, Dugger, Brittany N., Li, Zhe, Oehler, Abby, Bhardwaj, Sumita, Elepano, Manuel, Guan, Shenheng, Silber, B. Michael, Olson, Steven H., Prusiner, Stanley B.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2016
Subjects:
Drug Discovery and Translational Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4998675/
https://ncbi.nlm.nih.gov/pubmed/27317802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.235556
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