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Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice

Misfolding of tau proteins into prions and their propagation along neural circuits are thought to result in neurodegeneration causing Alzheimer’s disease, progressive supranuclear palsy, chronic traumatic encephalopathy, and other tauopathies. Little is known about the molecular processes mediating...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Johnson, Noah R., Condello, Carlo, Guan, Shenheng, Oehler, Abby, Becker, Julia, Gavidia, Marta, Carlson, George A., Giles, Kurt, Prusiner, Stanley B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754811/
https://ncbi.nlm.nih.gov/pubmed/29203673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717193114
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