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Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice

Misfolding of tau proteins into prions and their propagation along neural circuits are thought to result in neurodegeneration causing Alzheimer’s disease, progressive supranuclear palsy, chronic traumatic encephalopathy, and other tauopathies. Little is known about the molecular processes mediating...

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書目詳細資料
發表在:Proc Natl Acad Sci U S A
Main Authors: Johnson, Noah R., Condello, Carlo, Guan, Shenheng, Oehler, Abby, Becker, Julia, Gavidia, Marta, Carlson, George A., Giles, Kurt, Prusiner, Stanley B.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754811/
https://ncbi.nlm.nih.gov/pubmed/29203673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717193114
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