Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines

IMPORTANCE: Accumulation of the protein tau is a defining characteristic of several neurodegenerative diseases. Thorough assessment of transgenic (Tg) mouse lines that replicate this process is critical for establishing the models used for testing anti-tau therapeutics in vivo. OBJECTIVE: To define...

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Detalhes bibliográficos
Publicado no:JAMA Neurol
Main Authors: Woerman, Amanda L., Patel, Smita, Kazmi, Sabeen A., Oehler, Abby, Freyman, Yevgeniy, Espiritu, Lloyd, Cotter, Robert, Castaneda, Julian A., Olson, Steven H., Prusiner, Stanley B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2017
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5822201/
https://ncbi.nlm.nih.gov/pubmed/29059326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2017.2822
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