MSA prions exhibit remarkable stability and resistance to inactivation

In multiple system atrophy (MSA), progressive neurodegeneration results from the protein α-synuclein misfolding into a self-templating prion conformation that spreads throughout the brain. MSA prions are transmissible to transgenic (Tg) mice expressing mutated human α-synuclein (TgM83(+/−)), inducin...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Woerman, Amanda L., Kazmi, Sabeen A., Patel, Smita, Freyman, Yevgeniy, Oehler, Abby, Aoyagi, Atsushi, Mordes, Daniel A., Halliday, Glenda M., Middleton, Lefkos T., Gentleman, Steve M., Olson, Steven H., Prusiner, Stanley B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5756500/
https://ncbi.nlm.nih.gov/pubmed/28849371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-017-1762-2
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