Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines

Previously, we reported that intracranial inoculation of brain homogenate from multiple system atrophy (MSA) patient samples produces neurological disease in the transgenic (Tg) mouse model TgM83(+/−), which uses the prion protein promoter to express human α-synuclein harboring the A53T mutation fou...

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Publicado en:Acta Neuropathol
Autores principales: Woerman, Amanda L., Oehler, Abby, Kazmi, Sabeen A., Lee, Jisoo, Halliday, Glenda M., Middleton, Lefkos T., Gentleman, Steve M., Mordes, Daniel A., Spina, Salvatore, Grinberg, Lea T., Olson, Steven H., Prusiner, Stanley B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6454887/
https://ncbi.nlm.nih.gov/pubmed/30690664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-01959-4
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