Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines

Previously, we reported that intracranial inoculation of brain homogenate from multiple system atrophy (MSA) patient samples produces neurological disease in the transgenic (Tg) mouse model TgM83(+/−), which uses the prion protein promoter to express human α-synuclein harboring the A53T mutation fou...

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Pubblicato in:Acta Neuropathol
Autori principali: Woerman, Amanda L., Oehler, Abby, Kazmi, Sabeen A., Lee, Jisoo, Halliday, Glenda M., Middleton, Lefkos T., Gentleman, Steve M., Mordes, Daniel A., Spina, Salvatore, Grinberg, Lea T., Olson, Steven H., Prusiner, Stanley B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6454887/
https://ncbi.nlm.nih.gov/pubmed/30690664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-01959-4
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