Hybrid Enzalutamide Derivatives with Histone Deacetylase Inhibitor Activity Decrease Heat Shock Protein 90 and Androgen Receptor Levels and Inhibit Viability in Enzalutamide-Resistant C4-2 Prostate Cancer Cells

Histone deacetylase inhibitors (HDACIs) can disrupt the viability of prostate cancer (PCa) cells through modulation of the cytosolic androgen receptor (AR) chaperone protein heat shock protein 90 (HSP90). However, toxicities associated with their pleiotropic effects could contribute to the ineffecti...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Rosati, Rayna, Chen, Bailing, Patki, Mugdha, McFall, Thomas, Ou, Siyu, Heath, Elisabeth, Ratnam, Manohar, Qin, Zhihui
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4998664/
https://ncbi.nlm.nih.gov/pubmed/27382012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.103416
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados