Chronic p27(Kip1) Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor

Dexamethasone (Dex), co-administered to lung adenocarcinoma patients with pemetrexed chemotherapy, protects against pemetrexed cytotoxicity by inducing reversible G1 arrest, reflected by the effect of Dex on FLT-PET images of patient tumors. However, perioperative Dex treatment increases survival bu...

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Publicado en:Sci Rep
Autores principales: Patki, Mugdha, McFall, Thomas, Rosati, Rayna, Huang, Yanfang, Malysa, Agnes, Polin, Lisa, Fielder, Abigail, Wilson, Mike R., Lonardo, Fulvio, Back, Jessica, Li, Jing, Matherly, Larry H., Bepler, Gerold, Ratnam, Manohar
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207728/
https://ncbi.nlm.nih.gov/pubmed/30375484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34475-8
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