Hybrid Enzalutamide Derivatives with Histone Deacetylase Inhibitor Activity Decrease Heat Shock Protein 90 and Androgen Receptor Levels and Inhibit Viability in Enzalutamide-Resistant C4-2 Prostate Cancer Cells

Histone deacetylase inhibitors (HDACIs) can disrupt the viability of prostate cancer (PCa) cells through modulation of the cytosolic androgen receptor (AR) chaperone protein heat shock protein 90 (HSP90). However, toxicities associated with their pleiotropic effects could contribute to the ineffecti...

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Veröffentlicht in:Mol Pharmacol
Hauptverfasser: Rosati, Rayna, Chen, Bailing, Patki, Mugdha, McFall, Thomas, Ou, Siyu, Heath, Elisabeth, Ratnam, Manohar, Qin, Zhihui
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2016
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4998664/
https://ncbi.nlm.nih.gov/pubmed/27382012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.103416
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