The Amino-terminal Domain of the Androgen Receptor Co-opts Extracellular Signal-regulated Kinase (ERK) Docking Sites in ELK1 Protein to Induce Sustained Gene Activation That Supports Prostate Cancer Cell Growth

The ETS domain transcription factor ELK1 is in a repressive association with growth genes and is transiently activated through phosphorylation by ERK1/2. In prostate cancer (PCa) cells the androgen receptor (AR) is recruited by ELK1, via its amino-terminal domain (A/B), as a transcriptional co-activ...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Rosati, Rayna, Patki, Mugdha, Chari, Venkatesh, Dakshnamurthy, Selvakumar, McFall, Thomas, Saxton, Janice, Kidder, Benjamin L., Shaw, Peter E., Ratnam, Manohar
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2016
Sujets:
Gene Regulation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207070/
https://ncbi.nlm.nih.gov/pubmed/27793987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.745596
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