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Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification

p53 plays a pivotal role in tumour suppression under stresses, such as DNA damage. ISG15 has been implicated in the control of tumorigenesis. Intriguingly, the expression of ISG15, UBE1L and UBCH8 is induced by DNA-damaging agents, such as ultraviolet and doxorubicin, which are known to induce p53....

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Park, Jong Ho, Yang, Seung Wook, Park, Jung Mi, Ka, Seung Hyeun, Kim, Ji-Hoon, Kong, Young-Yun, Jeon, Young Joo, Seol, Jae Hong, Chung, Chin Ha
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996943/
https://ncbi.nlm.nih.gov/pubmed/27545325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12513
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