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Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification
p53 plays a pivotal role in tumour suppression under stresses, such as DNA damage. ISG15 has been implicated in the control of tumorigenesis. Intriguingly, the expression of ISG15, UBE1L and UBCH8 is induced by DNA-damaging agents, such as ultraviolet and doxorubicin, which are known to induce p53....
Zapisane w:
| Wydane w: | Nat Commun |
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| Główni autorzy: | , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Publishing Group
2016
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4996943/ https://ncbi.nlm.nih.gov/pubmed/27545325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12513 |
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