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ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway
Interferon (IFN)-induced signalling pathways have essential functions in innate immune responses. In response to type I IFNs, filamin B tethers RAC1 and a Jun N-terminal kinase (JNK)-specific mitogen-activated protein kinase (MAPK) module—MEKK1, MKK4 and JNK—and thereby promotes the activation of JN...
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2672892/ https://ncbi.nlm.nih.gov/pubmed/19270716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.23 |
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