UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity

Interferons (IFNs) regulate diverse cellular functions through activation of the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway. Lack of Ubp43, an IFN-inducible ISG15 deconjugating enzyme, leads to IFN hypersensitivity in ubp43−/− mice, suggesting an important funct...

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Main Authors: Malakhova, Oxana A, Kim, Keun I I, Luo, Jiann-Kae, Zou, Weiguo, Kumar, K G Suresh, Fuchs, Serge Y, Shuai, Ke, Zhang, Dong-Er
Formato: Artigo
Idioma:Inglês
Publicado: 2006
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1478183/
https://ncbi.nlm.nih.gov/pubmed/16710296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601149
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