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SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage
Heterogeneous ribonucleoprotein-K (hnRNP-K) is normally ubiquitinated by HDM2 for proteasome-mediated degradation. Under DNA-damage conditions, hnRNP-K is transiently stabilized and serves as a transcriptional co-activator of p53 for cell-cycle arrest. However, how the stability and function of hnRN...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
European Molecular Biology Organization
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3512394/ https://ncbi.nlm.nih.gov/pubmed/23092970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.293 |
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