SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage

Heterogeneous ribonucleoprotein-K (hnRNP-K) is normally ubiquitinated by HDM2 for proteasome-mediated degradation. Under DNA-damage conditions, hnRNP-K is transiently stabilized and serves as a transcriptional co-activator of p53 for cell-cycle arrest. However, how the stability and function of hnRN...

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Main Authors: Lee, Seong Won, Lee, Moon Hee, Park, Jong Ho, Kang, Sung Hwan, Yoo, Hee Min, Ka, Seung Hyun, Oh, Young Mi, Jeon, Young Joo, Chung, Chin Ha
Formáid: Artigo
Teanga:Inglês
Foilsithe: European Molecular Biology Organization 2012
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512394/
https://ncbi.nlm.nih.gov/pubmed/23092970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.293
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