Intratumoral oxygen gradients mediate sarcoma cell invasion

Hypoxia is a critical factor in the progression and metastasis of many cancers, including soft tissue sarcomas. Frequently, oxygen (O(2)) gradients develop in tumors as they grow beyond their vascular supply, leading to heterogeneous areas of O(2) depletion. Here, we report the impact of hypoxic O(2...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Lewis, Daniel M., Park, Kyung Min, Tang, Vitor, Xu, Yu, Pak, Koreana, Eisinger-Mathason, T. S. Karin, Simon, M. Celeste, Gerecht, Sharon
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2016
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995943/
https://ncbi.nlm.nih.gov/pubmed/27486245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605317113
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