Intratumoral oxygen gradients mediate sarcoma cell invasion

Hypoxia is a critical factor in the progression and metastasis of many cancers, including soft tissue sarcomas. Frequently, oxygen (O(2)) gradients develop in tumors as they grow beyond their vascular supply, leading to heterogeneous areas of O(2) depletion. Here, we report the impact of hypoxic O(2...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lewis, Daniel M., Park, Kyung Min, Tang, Vitor, Xu, Yu, Pak, Koreana, Eisinger-Mathason, T. S. Karin, Simon, M. Celeste, Gerecht, Sharon
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995943/
https://ncbi.nlm.nih.gov/pubmed/27486245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605317113
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