Intratumoral oxygen gradients mediate sarcoma cell invasion

Hypoxia is a critical factor in the progression and metastasis of many cancers, including soft tissue sarcomas. Frequently, oxygen (O(2)) gradients develop in tumors as they grow beyond their vascular supply, leading to heterogeneous areas of O(2) depletion. Here, we report the impact of hypoxic O(2...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Lewis, Daniel M., Park, Kyung Min, Tang, Vitor, Xu, Yu, Pak, Koreana, Eisinger-Mathason, T. S. Karin, Simon, M. Celeste, Gerecht, Sharon
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995943/
https://ncbi.nlm.nih.gov/pubmed/27486245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605317113
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