Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection

Major histocompatibility complex class II (MHC II) expression is tightly regulated, being subjected to cell type–specific mechanisms that closely control its levels at the cell surface. Ubiquitination by the E3 ubiquitin ligase MARCH 1 regulates MHC II expression in dendritic cells and B cells. In t...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Liu, Haiyin, Jain, Reema, Guan, Jing, Vuong, Vivian, Ishido, Satoshi, La Gruta, Nicole L., Gray, Daniel H., Villadangos, Jose A., Mintern, Justine D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995085/
https://ncbi.nlm.nih.gov/pubmed/27503069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160312
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