CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10–driven MARCH1-mediated ubiquitination and degradation

Effective vaccine adjuvants must induce expression of major histocompatability (MHC) class II proteins and the costimulatory molecule CD86 on dendritic cells (DCs). However, some adjuvants elicit production of cytokines resulting in adverse inflammatory consequences. Development of agents that selec...

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Main Authors: Tze, Lina E., Horikawa, Keisuke, Domaschenz, Heather, Howard, Debbie R., Roots, Carla M., Rigby, Robert J., Way, David A., Ohmura-Hoshino, Mari, Ishido, Satoshi, Andoniou, Christopher E., Degli-Esposti, Mariapia A., Goodnow, Christopher C.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023131/
https://ncbi.nlm.nih.gov/pubmed/21220452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20092203
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