The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection

The chikungunya virus (CHIKV) has become a substantial global health threat due to its massive re-emergence, the considerable disease burden and the lack of vaccines or therapeutics. We discovered a novel class of small molecules ([1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones) with potent in vitro acti...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Delang, L., Li, C., Tas, A., Quérat, G., Albulescu, I. C., De Burghgraeve, T., Guerrero, N. A. Segura, Gigante, A., Piorkowski, G., Decroly, E., Jochmans, D., Canard, B., Snijder, E. J., Pérez-Pérez, M. J., van Hemert, M. J., Coutard, B., Leyssen, P., Neyts, J.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992889/
https://ncbi.nlm.nih.gov/pubmed/27545976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31819
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